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		<updated>2026-04-21T18:28:35Z</updated>
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		<id>http://www.vokipedia.de/index.php?title=CBD_In_Pediatric_Care:_%22First_Do_No_Harm%22_Is_Primary_Consideration</id>
		<title>CBD In Pediatric Care: &quot;First Do No Harm&quot; Is Primary Consideration</title>
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				<updated>2025-11-28T10:16:35Z</updated>
		
		<summary type="html">&lt;p&gt;StuartTylor4682: &lt;/p&gt;
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&lt;div&gt;&amp;lt;br&amp;gt;The Agricultural Improvement Act of 2018 includes a provision that removes hemp-defined as cannabis with less than 0.3 percent tetrahydrocannabinol (THC), the psychoactive substance in marijuana-from the Controlled Substances Act. At the federal level, the provision makes it wholly legal to cultivate, possess, sell and distribute these strains of hemp, from which cannabidiol (CBD) oil is extracted. The legality of CBD at state levels varies. To access CBD oil legally in Missouri, patients must be approved to participate in the Missouri Hemp Extract Registration Program, available only to patients diagnosed with intractable epilepsy. Despite this, CBD is widely available in the state at stores specializing in CBD products, drugstores, supermarkets and even gas stations. In Illinois, CBD is legal as long as it meets federal guidelines for THC concentration. According to Washington University physician Jennifer Griffith, MD, PhD, a pediatric neurologist at St. Louis Children’s Hospital, this easy access to CBD in its various forms-oil, topical ointments, tinctures, vaping and edibles-is creating a new area of concern for pediatric subspecialists and community pediatricians.&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;quot;There is only one FDA-approved drug derived from a pure form of CBD oil, Epidiolex, which has proven effective in reducing seizures in some severe types of epilepsy,&amp;quot; she says. &amp;quot;Other than that, there have been no well-designed, randomized controlled trials to tell us if CBD is safe and effective for other conditions like mood disorders, inflammatory conditions or pain. In addition, there is little regulation over the CBD products manufactured. Dr. Griffith cites a study in which multiple CBD products available online were tested for their actual concentrations of cannabinoids. The results ranged widely, from products with negligible amounts of CBD to those with concentrations higher than that contained in the FDA-approved Epidiolex. &amp;quot;The study also found unlabeled THC in some of the products, which has big implications for an over-the-counter remedy some parents may want to give their children,&amp;quot; says Dr. Griffith. Dr. Griffith believes most parents who give their children CBD products are simply desperate to find something that helps.&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;quot;My approach with parents is to first find out why they decided to start their child on CBD, and then explain to them my concerns about CBD’s unknowns,  [https://curepedia.net/wiki/User:JulianneCairnduf Highline Wellness CBD official site] including its efficacy and safety long term,&amp;quot; she says. &amp;quot;I make it clear to them that even when I can’t recommend a CBD product, they need to keep me informed about what supplements they are giving their child. My goal is to maintain a therapeutic relationship with my patients and their parents so that anything I prescribe is safe for them in light of their CBD use.&amp;quot; Parents also need to be aware of [http://www.koha-community.cz/mediawiki/index.php?title=CBD_Dosage_For_Dogs:_How_Much_Should_I_Give_My_Dog Highline Wellness CBD official site]’s side effects, including sedation and generalized fatigue; insomnia; GI disturbances, especially nausea, vomiting and abdominal pain; and most seriously, liver toxicity. &amp;quot;Sharing my concerns about CBD allows parents to understand that I’m not trying to withhold something that could be helpful for their child. Rather, I’m looking out for their child’s best interest,&amp;quot; says Dr. Griffith.&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;Unlike CBD, marijuana, even that used for medical purposes, remains illegal at the federal level. Applications for medical marijuana are currently available in Missouri, and on January 1, 2020, marijuana will become legal for both medical and recreational use in Illinois. &amp;quot;In general, the state laws in Missouri and Illinois allow the same qualifying conditions for medical marijuana in both adults and children,&amp;quot; says Washington University physician Jennifer Griffith, MD, PhD, a pediatric neurologist at St. Louis Children’s Hospital. &amp;quot;That covers a wide variety of conditions, including cancer, inflammatory conditions, pain syndromes and epilepsy. In Missouri, medical marijuana use requires approval through the Department of Health and Senior Services. Patients fill out an application and once their physician signs it, they can take the application to a medical marijuana dispensary. &amp;quot;This is not a prescription from the doctor; rather, it’s a statement saying that the physician is caring for the patient, that the patient has a qualifying condition, and the doctor has discussed the use of medical marijuana with the patient,&amp;quot; says Dr. Griffith. As with CBD oil, the lack of research studies into the use of marijuana means there are questions regarding its efficacy and the consequences of long-term use. &amp;quot;Two complications exist for studies into marijuana use-there can be variability in what kinds of products people use, how much and how frequently they use them, and for what indications they are used. That makes measuring statistically and clinically significant effects really complicated,&amp;quot; explains Dr. Griffith. Another complication is the fact that today’s marijuana strains contain as much as five to tenfold more THC than those dating from earlier decades. &amp;quot;This means that when you look at the effects of marijuana use on people who started smoking in the 1970s and try to apply it to the products available today, there’s no correlation. Chemically and pharmaceutically, they are different products,&amp;quot; says Dr. Griffith.&amp;lt;br&amp;gt;&lt;/div&gt;</summary>
		<author><name>StuartTylor4682</name></author>	</entry>

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				<updated>2025-11-28T10:16:13Z</updated>
		
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		<id>http://www.vokipedia.de/index.php?title=Cannabidiol_CBD_:_A_Killer_For_Inflammatory_Rheumatoid_Arthritis_Synovial_Fibroblasts</id>
		<title>Cannabidiol CBD : A Killer For Inflammatory Rheumatoid Arthritis Synovial Fibroblasts</title>
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				<updated>2025-11-27T10:58:51Z</updated>
		
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&lt;div&gt;&amp;lt;br&amp;gt;In total, 40 patients with long-standing RA fulfilling the American College of Rheumatology revised criteria for RA (24) were included in this study. The RA group comprised of 32 females and 8 males with a mean age of 67.8 years ±10.5 years and 66.9 years ±8.2 years, respectively. C-reactive protein was 47.9 mg/dl ± 186.3 mg/dL for females and 28.7 mg/dL ± 43.2 mg/dL for males and rheumatoid factor was 184.4 iU/mL ± 280.4 iU/mL for females and 31.8 iU/mL ± 37.6 iU/mL for males. IN all, 11 out of 40 patients received glucocorticoids, 7 out of 40 methotrexate, 3 out of 40 biologicals, and 1 out of 40 a JAK inhibitor. All patients underwent elective knee joint replacement surgery, and they were informed about the purpose of the study and gave written consent. Samples from RA synovial tissue were isolated and prepared as described previously22 (for details see also Supplementary methods). G8080) according to manufacturer’s instructions. P6866) for 60 min at 37 °C followed by 30 min at room temperature.&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;P3584) and respective antagonists/ligands/inhibitors were added for 30 min at room temperature. PoPo3 uptake were evaluated with a TECAN multimode reader over 90 min. RASF were trypsinized, washed and fixed for 20 min with 3.7% formaldehyde (F8775, Sigma Aldrich). Cells were permeabilized with 0.1% Triton X-100 (X100, Sigma) in PBS for 10 min. Then, 0.2 µg/50 µl primary antibody (Proteintech, 19124-1-AP) was added for 2 h. The secondary antibody (Abcam, goat anti-rabbit IgG H&amp;amp;L (Alexa Fluor® 488), ab150077) was incubated for 1 h. Cells were analyzed using a MACS Quant 9 analyzer (Miltenyi Biotec, Bergisch Gladbach, Germany). Statistical analysis was performed with SPSS 25 (IBM, Armonk, USA). The statistic tests used are given in the figure legends. Normal distribution was determined using the Shapiro-Wilk test, equal variance was determined by Levene’s test. In the case of equal variance, the Bonferroni post-hoc test was used, otherwise the Dunnet’s post-hoc test was employed. When data are presented as box plots, the boxes represent the 25th to 75th percentiles, the lines within the boxes represent the median, and the lines outside the boxes represent the 10th and 90th percentiles. When data are presented as line plots, the line represents the mean. When data are presented as bar charts, the top of the bar represents the mean and error bars depict the standard error of the mean (sem).&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;If you're dipping your toes into the infused beverage space, these businesses can help you get started. As cannabis regulation continues to evolve across the United States and around the world, please be mindful of your local laws and regulations. Alcoholism runs deep in both sides of my family. To prevent possibly continuing those patterns as I get older, I’ve become more interested in exploring other options for social drinking; Alcohol-free wines and spirits have become significantly more accessible in recent years, and cannabis-based mocktails is one of the most interesting trends in this space. Picture a zero-proof drink with all the layers of flavor we’ve come to love in a cocktail, but with a THC and/or [https://adoremon.vn/ViewSwitcher/SwitchView?mobile=False&amp;amp;returnUrl=https://championsleage.review/wiki/User:Patti21F56772882 CBD] mixture that can be customized for the exact high you’d like to experience. While this trend is spreading, conversations around race and cannabis need to remain at the forefront of this movement.&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;With Black cannabis entrepreneurs accounting for less than 2% of businesses in this multi-billion dollar industry, the politics around all things cannabis still live in the shadow of the effects of DARE (an anti-drug program that was very popular in the 90’s and early 2000’s that also helped to push the criminalization and stigmatization of recreational cannabis to children),  [http://www.vokipedia.de/index.php?title=Benutzer:StuartTylor4682 cbd] the Reagan-era’s war on drugs, as well as a longer legacy of racism in the United States. The first cannabis mocktail I ever tried was in Rose Mary Jane, a Black woman-owned, equity-owned canna-bar and lounge in Oakland, California. This location is also a community event center and a dispensary for cannabis products, with a focus on local producers such as Maat Apothecary (their spiced honey is a favorite of mine) and New Life, a flower hybrid that’s ideal for being social and adventurous. In the near future, Rose Mary Jane’s team plans to host classes for people interested in all things cannabis.&amp;lt;br&amp;gt;&lt;/div&gt;</summary>
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		<id>http://www.vokipedia.de/index.php?title=CBD_Oil:_What_Are_9_Proven_Or_Possible_Health_Benefits</id>
		<title>CBD Oil: What Are 9 Proven Or Possible Health Benefits</title>
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				<updated>2025-11-26T14:41:41Z</updated>
		
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&lt;div&gt;&amp;lt;br&amp;gt;CBD Oil: What are 9 Proven or Possible Health Benefits? Medically reviewed by Carmen Pope, BPharm. With a forecasted revenue of over 20 billion by 2024, the CBD market is booming.1 But what exactly is CBD and how effective is it? We look at 9 proven or possible health benefits of CBD oil. CBD (short for cannabidiol) is one of over 200 chemical compounds known as cannabinoids that are found in cannabis. Cannabis is a plant, and there are two main types, Cannabis Indica and Cannabis Sativa. Both marijuana and CBD can be derived from both types, but hemp is only derived from Cannabis Sativa. By law, hemp must contain no more than 0.3% THC (the oil in marijuana that gives you a high) to be called hemp, otherwise, growers are at risk of prosecution under federal law. Hemp is a great resource for making 100% biodegradable, environmentally friendly products such as clothing, packaging, biofuel, building materials, and paper.&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;CBD derived from hemp contains no more than 0.3% THC and is legal federally but still illegal under some state laws. Cannabis-derived CBD products, on the other hand, are illegal federally but legal under some state laws. Unlike THC, CBD has no psychoactive properties and will not give you a &amp;quot;high&amp;quot;. There is no evidence it has any abuse or dependence potential and to date, there is no evidence that it is associated with any serious side effects, according to the World Health Organization. Instead, CBD has been credited with relieving numerous medical conditions, such as epilepsy, anxiety, inflammation, insomnia, and pain. Although &amp;quot;credited&amp;quot; does not mean proven. Because of the historical regulatory landscape, there are hardly any well-conducted trials backing up those claims, although research is expected to ramp up now that laws distinguish between hemp and marijuana. We look at nine medical conditions where CBD may be, or, has already proven to be, beneficial. In June 2018, the FDA approved Epidiolex (a plant-based formulation of CBD) to treat seizures for people 2 years of age and older with Dravet syndrome and Lennox-Gastaut syndrome (LGS), which are two rare forms of epilepsy.&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;CBD has also been investigated for use in other forms of treatment-resistant epilepsy, usually in addition to conventional epilepsy medications. CBD can interact with other medications used for epilepsy and some serious side effects have been reported,  [https://opnlink.com/o/JLXar www.highlinewellnesscbd.org] notably, a decrease in liver function when given to people already taking valproate. Conclusion: CBD is beneficial for treating certain types of epilepsy. Animal studies have shown that CBD has anti-inflammatory effects and works on the endocannabinoid and pain-sensing systems to relieve pain. Unfortunately, few human trials investigating the use of CBD as a single agent to relieve pain exist, with most trials using a combination of CBD and THC to relieve pain. Notably, Health Canada has approved a combination medication that contains both THC and CBD in a 1:1 ratio for the relief of central nerve-related pain in multiple sclerosis, and cancer pain that is unresponsive to optimized opioid therapy. A case series of 47 people with multiple sclerosis reported improvements in pain, walking, and muscle spasms with a combination of CBD and  [http://www.vokipedia.de/index.php?title=Benutzer:StuartTylor4682 vokipedia.de] THC.&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;&amp;lt;br&amp;gt;Animal studies have shown that CBD has a positive effect on serotonin levels in the brain, and serotonin. Other research (both animal and human) has shown that CBD has anti-inflammatory effects, and it may relieve pain by this mechanism. CBD can interact with other medications used to treat heart conditions or immunosuppressants so you should always talk with your doctor before taking CBD. Conclusion: CBD may be beneficial at relieving pain but no high-quality human studies prove this. Animal studies showed that topical CBD applications relieve pain and inflammation associated with arthritis with few side effects. The topical application of CBD is beneficial because CBD is poorly absorbed when taken by mouth and can cause gastrointestinal side effects. Conclusion: Topical CBD may be beneficial at relieving arthritis but no high-quality human studies prove this. What are CBD gummies? Are there any health benefits? How long does Marijuana stay in your system?&amp;lt;br&amp;gt;&lt;/div&gt;</summary>
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		<title>CBD Vape Juice</title>
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				<updated>2025-10-18T15:24:47Z</updated>
		
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